Here is an example of such a monster patch: https://phabricator.haskell.org/D246
On my machine, just loading the page pegs my CPU for a while. After it quiesces, I can scroll a bit, but now most UI interactions (e.g. clicking a line number to add an inline comment) have a three to four second lag. This is on Chrome; Firefox is almost nearly completely unusable.
I'm not really sure how you'd go about fixing this; maybe lightening up on the JavaScript/HTML styling on really big pages to something minimal but which works. But maybe at least, the tools should warn if your diff is too big for the tools to handle reasonably.