diff --git a/src/aphront/configuration/AphrontApplicationConfiguration.php b/src/aphront/configuration/AphrontApplicationConfiguration.php
--- a/src/aphront/configuration/AphrontApplicationConfiguration.php
+++ b/src/aphront/configuration/AphrontApplicationConfiguration.php
@@ -286,6 +286,7 @@
       $original_exception = $ex;
     }
 
+    $response_exception = null;
     try {
       if ($original_exception) {
         $response = $this->handleThrowable($original_exception);
@@ -296,7 +297,13 @@
       $response->setRequest($request);
 
       self::writeResponse($sink, $response);
-    } catch (Exception $response_exception) {
+    } catch (Exception $ex) {
+      $response_exception = $ex;
+    } catch (Throwable $ex) {
+      $response_exception = $ex;
+    }
+
+    if ($response_exception) {
       // If we encountered an exception while building a normal response, then
       // encountered another exception while building a response for the first
       // exception, just throw the original exception. It is more likely to be
diff --git a/support/startup/PhabricatorStartup.php b/support/startup/PhabricatorStartup.php
--- a/support/startup/PhabricatorStartup.php
+++ b/support/startup/PhabricatorStartup.php
@@ -315,7 +315,7 @@
    *
    * @param   string    Brief description of the exception context, like
    *                    `"Rendering Exception"`.
-   * @param   Exception The exception itself.
+   * @param   Throwable The exception itself.
    * @param   bool      True if it's okay to show the exception's stack trace
    *                    to the user. The trace will always be logged.
    * @return  exit      This method **does not return**.
@@ -324,7 +324,7 @@
    */
   public static function didEncounterFatalException(
     $note,
-    Exception $ex,
+    $ex,
     $show_trace) {
 
     $message = '['.$note.'/'.get_class($ex).'] '.$ex->getMessage();
diff --git a/webroot/index.php b/webroot/index.php
--- a/webroot/index.php
+++ b/webroot/index.php
@@ -2,6 +2,7 @@
 
 phabricator_startup();
 
+$fatal_exception = null;
 try {
   PhabricatorStartup::beginStartupPhase('libraries');
   PhabricatorStartup::loadCoreLibraries();
@@ -12,25 +13,65 @@
   PhabricatorStartup::beginStartupPhase('sink');
   $sink = new AphrontPHPHTTPSink();
 
+  // PHP introduced a "Throwable" interface in PHP 7 and began making more
+  // runtime errors throw as "Throwable" errors. This is generally good, but
+  // makes top-level exception handling that is compatible with both PHP 5
+  // and PHP 7 a bit tricky.
+
+  // In PHP 5, "Throwable" does not exist, so "catch (Throwable $ex)" catches
+  // nothing.
+
+  // In PHP 7, various runtime conditions raise an Error which is a Throwable
+  // but NOT an Exception, so "catch (Exception $ex)" will not catch them.
+
+  // To cover both cases, we "catch (Exception $ex)" to catch everything in
+  // PHP 5, and most things in PHP 7. Then, we "catch (Throwable $ex)" to catch
+  // everything else in PHP 7. For the most part, we only need to do this at
+  // the top level.
+
+  $main_exception = null;
   try {
     PhabricatorStartup::beginStartupPhase('run');
     AphrontApplicationConfiguration::runHTTPRequest($sink);
   } catch (Exception $ex) {
+    $main_exception = $ex;
+  } catch (Throwable $ex) {
+    $main_exception = $ex;
+  }
+
+  if ($main_exception) {
+    $response_exception = null;
     try {
       $response = new AphrontUnhandledExceptionResponse();
-      $response->setException($ex);
+      $response->setException($main_exception);
 
       PhabricatorStartup::endOutputCapture();
       $sink->writeResponse($response);
-    } catch (Exception $response_exception) {
-      // If we hit a rendering exception, ignore it and throw the original
-      // exception. It is generally more interesting and more likely to be
-      // the root cause.
-      throw $ex;
+    } catch (Exception $ex) {
+      $response_exception = $ex;
+    } catch (Throwable $ex) {
+      $response_exception = $ex;
+    }
+
+    // If we hit a rendering exception, ignore it and throw the original
+    // exception. It is generally more interesting and more likely to be
+    // the root cause.
+
+    if ($response_exception) {
+      throw $main_exception;
     }
   }
 } catch (Exception $ex) {
-  PhabricatorStartup::didEncounterFatalException('Core Exception', $ex, false);
+  $fatal_exception = $ex;
+} catch (Throwable $ex) {
+  $fatal_exception = $ex;
+}
+
+if ($fatal_exception) {
+  PhabricatorStartup::didEncounterFatalException(
+    'Core Exception',
+    $fatal_exception,
+    false);
 }
 
 function phabricator_startup() {