diff --git a/src/applications/config/check/PhabricatorMailSetupCheck.php b/src/applications/config/check/PhabricatorMailSetupCheck.php
--- a/src/applications/config/check/PhabricatorMailSetupCheck.php
+++ b/src/applications/config/check/PhabricatorMailSetupCheck.php
@@ -64,6 +64,19 @@
             ->addPhabricatorConfig('amazon-ses.secret-key');
         }
 
+        if (!PhabricatorEnv::getEnvConfig('amazon-ses.endpoint')) {
+          $message = pht(
+            'Amazon SES is selected as the mail adapter, but no SES endpoint '.
+            'is configured. Provide an SES endpoint or choose a different '.
+            'mail adapter.');
+
+          $this->newIssue('config.amazon-ses.endpoint')
+            ->setName(pht('Amazon SES Endpoint Not Set'))
+            ->setMessage($message)
+            ->addRelatedPhabricatorConfig('metamta.mail-adapter')
+            ->addPhabricatorConfig('amazon-ses.endpoint');
+        }
+
         $address_key = 'metamta.default-address';
         $options = PhabricatorApplicationConfigOptions::loadAllOptions();
         $default = $options[$address_key]->getDefault();
diff --git a/src/applications/config/option/PhabricatorAWSConfigOptions.php b/src/applications/config/option/PhabricatorAWSConfigOptions.php
--- a/src/applications/config/option/PhabricatorAWSConfigOptions.php
+++ b/src/applications/config/option/PhabricatorAWSConfigOptions.php
@@ -27,6 +27,18 @@
       $this->newOption('amazon-ses.secret-key', 'string', null)
         ->setHidden(true)
         ->setDescription(pht('Secret key for Amazon SES.')),
+      $this->newOption('amazon-ses.endpoint', 'string', null)
+        ->setLocked(true)
+        ->setDescription(
+          pht(
+            'SES endpoint domain name. You can find a list of available '.
+            'regions and endpoints in the AWS documentation.'))
+        ->addExample(
+          'email.us-east-1.amazonaws.com',
+          pht('US East (N. Virginia, Older default endpoint)'))
+        ->addExample(
+          'email.us-west-2.amazonaws.com',
+          pht('US West (Oregon)')),
       $this->newOption('amazon-s3.access-key', 'string', null)
         ->setLocked(true)
         ->setDescription(pht('Access key for Amazon S3.')),
diff --git a/src/applications/metamta/adapter/PhabricatorMailImplementationAmazonSESAdapter.php b/src/applications/metamta/adapter/PhabricatorMailImplementationAmazonSESAdapter.php
--- a/src/applications/metamta/adapter/PhabricatorMailImplementationAmazonSESAdapter.php
+++ b/src/applications/metamta/adapter/PhabricatorMailImplementationAmazonSESAdapter.php
@@ -23,12 +23,13 @@
   public function executeSend($body) {
     $key = PhabricatorEnv::getEnvConfig('amazon-ses.access-key');
     $secret = PhabricatorEnv::getEnvConfig('amazon-ses.secret-key');
+    $endpoint = PhabricatorEnv::getEnvConfig('amazon-ses.endpoint');
 
     $root = phutil_get_library_root('phabricator');
     $root = dirname($root);
     require_once $root.'/externals/amazon-ses/ses.php';
 
-    $service = new SimpleEmailService($key, $secret);
+    $service = new SimpleEmailService($key, $secret, $endpoint);
     $service->enableUseExceptions(true);
     return $service->sendRawEmail($body);
   }
diff --git a/src/docs/user/configuration/configuring_outbound_email.diviner b/src/docs/user/configuration/configuring_outbound_email.diviner
--- a/src/docs/user/configuration/configuring_outbound_email.diviner
+++ b/src/docs/user/configuration/configuring_outbound_email.diviner
@@ -135,6 +135,7 @@
     "PhabricatorMailImplementationAmazonSESAdapter".
   - **amazon-ses.access-key**: set to your Amazon SES access key.
   - **amazon-ses.secret-key**: set to your Amazon SES secret key.
+  - **amazon-ses.endpoint**: Set to your Amazon SES endpoint.
 
 NOTE: Amazon SES **requires you to verify your "From" address**. Configure which
 "From" address to use by setting "`metamta.default-address`" in your config,